Get Analytical Mechanics, Seventh Edition, International Student PDF

By Grant R. Fowles, George L. Cassiday

ISBN-10: 0534408133

ISBN-13: 9780534408138

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Extra resources for Analytical Mechanics, Seventh Edition, International Student Edition

Example text

It has been proposed that these receptors serve a storage or clearance function, since biologically inert analogues of ANF which retain affinity for this class of receptor raise circulating levels of ANF (84). The stimulation of particulate guanylate cyclase by ANF (74), is an action which is unique among known mammalian hormones. Other substances including nitrates and EDRF also increase cellular cGMP levels, but by activating the soluble (cytosolic) form of guanylate cyclase (83). g. on adrenal (57».

The significance of these results is unclear. ANF infusions which yield such modest increases do not cause the same degree of natriuresis or renin suppression as does high salt intake. In animals, neither atrial appendectomy nor immunization against ANF grossly disturb the ability to achieve sodium balance (104, 105). In studies of escape from the sodium retention due to mineralocorticoid excess, ANF levels rise (118, 119), but auto-immunization against ANF does not alter the changes in sodium excretion during mineralocorticoid escape (105).

Such an effect would be more likely in heart failure where levels are extremely high, than in cirrhosis (106) or nephrosis (130) where elevations are modest. Despite the failure to accelerate sodium loss, ANF infusions can lower systemic resistance and pulmonary capillary wedge pressure in patients with heart failure (20, 43), suggesting that the hormone may playa protective role in this disorder. In summary, ANF occupies a strategic position in the network of systems which maintain intravascular volume homeostasis.

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Analytical Mechanics, Seventh Edition, International Student Edition by Grant R. Fowles, George L. Cassiday


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